Dehydroepiandrosterone Sulfate Reduces Acoustic Injury of the Guinea-Pig Cochlea
نویسندگان
چکیده
منابع مشابه
Acoustic stimulation increases phosphoinositide breakdown in the guinea pig cochlea.
The effect of sound stimulation on phosphoinositide turnover was investigated in the inner ear of the guinea pig. The perilymphatic spaces of the cochlea were perfused with [(32)P]orthophosphate ((32)P(i)) and labeled lipids analyzed in the tissues of the lateral wall of the cochlea (stria vascularis and spiral ligament) and the basilar membrane (organ of Corti). Consistent with previous result...
متن کاملAcoustic stimulation promotes DNA fragmentation in the Guinea pig cochlea.
Apoptosis can be described as programmed cell death. Apoptosis regulates cell turnover and is involved in various pathological conditions. The characteristic features of apoptosis are shrinkage of the cell body, chromatin condensation, and nucleic acid fragmentation. During apoptosis, double-stranded DNA is broken down into single-stranded DNA (ssDNA) by proteases. Acoustic trauma is commonly e...
متن کامل17β-Estradiol reduces nitric oxide production in the Guinea pig cochlea.
Intense noise exposure and the application of ototoxic substances result in increased levels of reactive oxygen species (ROS) and reactive nitrogen species (RNS), such as nitric oxide (NO). In order to reduce the free NO concentration in the inner ear under pathological conditions, the use of natural cytoprotective substances such as 17β-estradiol is a promising therapeutic concept. In male gui...
متن کاملAcute perilymphatic perfusion of the guinea pig cochlea.
A method for the continuous perfusion of the perilymphatic space of the inner ear in the guinea pig is described. Artificial perilymph is supplied to the cochlea and drained away through a tubing system while flow rates from 10 microliters/min to 0.3 ml/min are established by gravity syphon pressure. Techniques are also presented which allow control over the temperature of the perfusate and ov...
متن کاملImmunocytochemical localization of glutamate immunoreactivity in the guinea pig cochlea.
The localization of glutamate immunoreactivity was examined in the guinea pig cochlea using affinity purified polyclonal antibodies to glutamate and immunoperoxidase post-embedding staining techniques on one micron plastic sections. Glutamate immunoreactive staining was seen in both inner and outer hair cells and in spiral ganglion cells and auditory nerve fibers. These results support the hypo...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Pharmacological Sciences
سال: 2005
ISSN: 1347-8613,1347-8648
DOI: 10.1254/jphs.scz050443